![]() ![]() Then, machine learning models are used to cluster the SNVs into subclones and reconstruct the tumor phylogenetic trees 9. First, bulk sequencing provides mixed information about genetic alterations for all subclones in the tumor, including allele frequency for single-nucleotide variations (SNVs) and copy number alteration (CNA). The workflow generally consists of two parts. In recent years, strategies have been developed by combining deep whole-genome sequencing (WGS) or whole-exome sequencing (WES) with novel statistical and computational methods. However, this strategy may not be suitable under all circumstances because of the ethics of carrying out unnecessary invasive procedures as well as the practicality of longitudinal sampling for solid tumors, since the majority of cancer samples are obtained from surgical procedures, and if a tumor has been removed at the one-time point, it will not be available for sampling at a later time point 3. One strategy to deconvolute spatial and temporal tumor heterogeneity is to perform multiregional and longitudinal sampling 2. Hence, dissecting the clonal composition of a tumor not only helps us to understand its biology and evolution but also guides the design of combinatorial therapies 2. Therefore, when targeted therapy exerts its selection pressure, subclones with drug-resistant mutations would gradually dominate due to selective advantage 8. Spatial heterogeneity refers to the phenomenon that a tumor is composed of subclones of different genetic background 5, 6, and temporal heterogeneity refers to the dynamic evolution of the tumor genomes through the disease course 7. This heterogeneity is both spatial and temporal 3, 5, 6, 7. Tumor heterogeneity is a major contributor to the development of drug resistance 1, 2, 3, 4. Targeted therapy, a widely adopted cancer treatment 1, might have the potential to elicit promising initial responses, but many patients develop drug resistance during treatment 2, 3. ![]()
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![]() ![]() ![]() ![]() Spotify Premium is the general term used for paid-for Spotify subscriptions. The premium account lets you access all the features offered by the music streaming service and eliminates advertisements. Playback restrictions are eliminated. What Is Spotify Premium? The premium account 3.3 The Spotify Family-$15.99 per month.3.1 The Spotify Individual -$9.99 per month.2.4 Limitless skips, replays, and repeats.“Never before have students had this level of streaming entertainment options, at this unprecedented value, all in one package. students-both the millions already on Spotify Premium and those who are new-really is huge. “By joining forces with SHOWTIME and continuing our relationship with Hulu, Spotify Premium is now able to give students a complete world of music and video content, shows and film. “Never before have students had this level of streaming entertainment options, at this unprecedented value, all in one package.” Showtime has now been added to the the plan, offering a wider selection of TV programming and movies.Īlex Norström, Chief Premium Officer, Spotify said: “Spotify Premium has just changed the content game for students. The current Spotify Premium for Students plan offers unlimited and on-demand access to music and podcasts for $4.99, as well as a subscription to Hulu’s streaming library of TV and movie hits. That winky smile might not go down too well in major label land.Ī number of senior execs recently told us that they are closely following Spotify’s ARPU, which has seen a perilous decline in recent years – largely thanks to a combination of telco bundles, Family and Student Plans, plus market-sensitive pricing.Īccording to MBW’s calculations based on Spotify’s fiscal filings, the average Spotify subscriber worldwide is now paying approximately USD $30 less per year for their account than they were in 2015 ($8.16 per month in 2015 vs. Announcing the cheap trial, a Spotify blog post reads: because we know students have plenty of other things they want to spend their money on - textbooks, for example )’ ![]() ![]() ![]() ![]() "It should be noted that a single-vector PMSSDP reflection/amplification attack of ~2 Gbps – ~3 Gbps in size is often sufficient to have a significant negative impact on the availability of targeted networks/servers/services."Īccording to Netscout, upwards of 27,000 Plex Media Servers have been used for amplification DDoS attacks to-date. "PMSSDP has been weaponized and added to the arsenals of so-called ‘booter/stresser’ DDoS-for-hire services, placing it within the reach of the general attacker population," writes Netscout. With a multi-factor attack, traffic could elevate to 218 Gbps. Plex Media Servers are used to amplify PMSSDP packets by a factor of roughly 4.68, with single-vector PMSSDP DDoS attacks delivering between 2 Gbps to 3 Gbps of traffic. However, Plex's UPnP service gives direct access to the internet, which makes it a prime victim for a reflection/amplification DDoS attack vector using UDP port 32414. This allows the Plex Media SSDDP service access to the internet so, for example, you could use your iPad Pro with cellular connectivity to access your home Plex Media Server to play your old Friends reruns while on the other side of the United States. If your router is Simple Service Discovery Protocol (SSDP) enabled, Plex Media Server will attempt to use Universal Plug and Play (UPnP) to enable dynamic NAT forwarding. Plex Media Server uses the G’Day Mate (GDM) network/service discovery protocol to initially find other compatible media/streaming devices on your local network. However, the company's central user-facing Plex Media Server, which is accessed via a web interface on multiple platforms (including Windows and macOS), is reportedly being used to aid in distributed denial of service (DDoS) attacks according to a security bulletin from Netscout. Over the years, Plex has grown to include features like Live TV, podcasts, and even retro gaming to broaden its appeal to everyday users. Plex is a widely popular platform that allows you to curate all your media on a home server and stream it either within your home or over the internet to other PCs, Macs, smartphones, or tablets. ![]() ![]() ![]() Not only are all of the Sysinternals utilities mentioned in this article available for download/installation from the Windows Sysinternals website but most also run live from their "home pages" in the Sysinternals area on the Microsoft website. Nevertheless, we can state with absolute finality and security that all our choices are bound to be both useful and informative, and that looking for more choices will only result in the discovery of further treasures. Picking the top five from Sysinternals is not unlike picking the five best artworks by Leonardo da Vinci or the five best symphonies by Mozart: No matter which ones you pick, they're bound to be good, but there's also bound to be disagreement from other cognoscenti with different tastes or objectives who have their own favorites to push and promote. Our top five, as well as the rest of the over 100 other utilities you'll find there, are all worth digging into, and getting to know. Although Sysinternals is now part of Microsoft-and one of its primary principals, Mark Russinovich, is now a Microsoft Technical Fellow-the Sysinternals name has been well-recognized since the mid-1990s when it burst onto the scene with some superlative Windows utilities.Įverything you'll find in this article is available from the Microsoft Windows Sysinternals web pages (now called Microsoft Sysinternals) for free. Sysinternals is a company name to conjure within the Windows community. Here, we profile a handful of tools that Windows users of all stripes are likely to find invaluable. Long known for their power and capability, they're both free and incredibly useful. The Sysinternals utilities for Windows offer some of the best diagnostic and troubleshooting tools around. ![]() ![]() ![]() By the time they got me to the hospital, I had almost bled to death internally. In order to get sort of medical care, you have to be helicoptered off the island if it’s an emergency. I lived – I grew up on this remote island, not super remote, but you have to get there by ferry boat up in Washington State. I took a really weird hard fall, where I actually sort of got caught up with my legs caught up on somebody’s shoulder and fell down really hard. But I was in high school and playing basketball. I want to start where perhaps many of your interviews have started, your lack of a spleen. Pete, thank you so much for having me, really excited about it. Jake, thanks so much for joining us here on the How to be Awesome at Your Job podcast. Previous episode: 148: Optimizing Sleep for Sharper Performance with Dr.Previous episode: 310: Managing Your Energy to Perform at Your Best with Tony Schwartz.Research: The Cost of Interrupted Work: More Speed and Stress.Book: The Power of Moments: Why Certain Experiences Have Extraordinary Impact by Chip and Dan Heath.Book: Made to Stick: Why Some Ideas Survive and Others Die by Chip and Dan Heath.Book: Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School by John Medina.Jake’s book: Sprint: How to Solve Big Problems and Test New Ideas in Just Five Days.Jake’s book: Make Time: How to Focus on What Matters Every Day.Sponsored message: Phonetic Eyewear helps combat digital eyestrain.Sponsored message: BetterHelp makes therapy more accessible.He is currently among the world’s tallest designers. Previously, Jake helped build products like Gmail, Google Hangouts, and Microsoft Encarta. He has since coached teams like Slack, Uber, 23andMe, LEGO, and The New York Times on the method. Jake spent 10 years at Google and Google Ventures, where he created the Design Sprint. Approaches to clear out distractions for laser focus. ![]()
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Our top website pick for downloading PC games in 2022 is FitGirl Repacks. FitGirl Repacksĭownload type: Torrents and user-uploaded DDL Note that if you are looking exclusively for older games, we have an article reviewing the best websites for downloading old PC games. Note that this list is not exhaustive and many popular websites will be skipped, but this is nevertheless an accurate review of the top websites to download PC games for free in 2022. ![]() This educational post provides a list of the most popular websites to download pirated PC games for free. While this is considered piracy and is illegal in most countries, it is still a very common practice. Instead of spending hundreds of dollars buying random games on Steam and GOG.com, many users prefer downloading them for free. During the pandemic, more and more gamers found themselves stuck at home with nothing to do. Downloading PC Games for free is no new thing – in fact since the time people were playing DOS games in the 90s, there have been video game crackers and copyright protection for games. ![]() ![]() ![]() The process of download can be started by the user by just click the download button given on the screen after which the process of download starts which takes some time and soon firefox offline installer download in your system. Mozilla firefox free download for windows 10 as the simple process of the download. How Do I Download and Install Mozilla Firefox on My PC? The interface of Mozilla Firefox offline installer is simple and catchy due to which it is easy to use. Mozilla firefox updates itself automatically when it needed. Mozilla Firefox download for windows 7 64 bitĭue to security threats, most of the users avoid all the browsers except the latest Mozilla firefox free download for windows 7. 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